Diastereoselective three-component reactions of chiral nickel(II) glycinate for convenient synthesis of novel α-amino-β-substituted-γ,γ-disubstituted butyric acids.
نویسندگان
چکیده
The convenient, high yielding and diastereoselective synthesis of α-amino-β-substituted-γ,γ-disubstituted butyric acid derivatives was carried out by a three-component tandem reaction of a chiral equivalent of nucleophilic glycine. The reaction was performed smoothly under mild conditions and enabled the construction of two or three adjacent chiral centers in one step, thus affording a novel and convenient route to α-amino-β-substituted-γ,γ-disubstituted butyric acid derivatives.
منابع مشابه
Base-Promoted Synthesis of β-Substituted-Tryptophans via a Simple and Convenient Three-Component Condensation of Nickel(II) Glycinate.
A three-component reaction of nickel(II) glycinate was conducted for the convenient synthesis of β-substituted-tryptophans. The reaction worked smoothly under mild conditions and the procedure was simple and easy to handle.
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ورودعنوان ژورنال:
- Molecules
دوره 19 1 شماره
صفحات -
تاریخ انتشار 2014